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Structural Insights into the Role of Mutations in Amyloidogenesis

4 Sept 2008

Abstract excerpt

Mechanisms of amyloidogenesis are not well understood, including potential structural contributions of mutations in the process. Our previous research indicated that the dimer interface of amyloidogenic immunoglobulin light chain protein AL-09 is twisted 90 degrees relative to the protein from its germline sequence, kappaI O18/O8. Here we report a systematic restoration of AL-09 to its germline sequence by...

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PMID: 18768467
DOI: 10.1074/jbc.m804822200

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