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Article

Mutational and genetic determinants of λ6 light chain amyloidogenesis.

The FEBS journal - 1 Dec 2013

González-Andrade Martín, Becerril-Luján Baltazar, Sánchez-López Rosana, Ceceña-Álvarez Héctor, Pérez-Carreón Julio I, Ortiz Ernesto, Fernández-Velasco D Alejandro, del Pozo-Yauner Luis

Abstract excerpt

Approximately 25% of the λ6 light chains have glycine rather than arginine at position 25, which is an allelic variant of the IGLV6-57 (6a) locus. The Gly25 variant has been shown to decrease the folding stability of the germline λ6 V(L) protein 6aJL2 by 1.7 kcal·mol(-1). In this work, we compared the thermodynamic and fibrillogenic properties of the amyloidosis (AL) derived recombinant (r) V(L) protein AR, which...

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Identifiers

PMID: 24107228
DOI: 10.1111/febs.12538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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