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Article

Convergent mechanisms favor fast amyloid formation in two lambda 6a Ig light chain mutants.

Biopolymers - 1 Aug 2017

Valdés-García Gilberto, Millán-Pacheco César, Pastor Nina

Abstract excerpt

Extracellular deposition as amyloids of immunoglobulin light chains causes light chain amyloidosis. Among the light chain families, lambda 6a is one of the most frequent in light chain amyloidosis patients. Its germline protein, 6aJL2, and point mutants, R24G and P7S, are good models to study fibrillogenesis, because their stability and fibril formation characteristics have been described. Both mutations make the...

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PMID: 28509352
DOI: 10.1002/bip.23027

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