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Influence of the germline sequence on the thermodynamic stability and fibrillogenicity of human lambda 6 light chains

7 Feb 2008

Abstract excerpt

Light chain-associated amyloidosis is a fatal disease characterized by the aggregation and pathologic deposition of monoclonal light chain-related fragments as amyloid fibrils in organs or tissues throughout the body. Notably, it has been observed that proteins encoded by the lambda variable light chain (V(L)) gene segment 6a are invariably associated with amyloid deposition; however, the contribution of the gene...

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PMID: 18260098
DOI: 10.1002/prot.21934

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