Article
Allogeneic transplantation for AML and MDS: GVL versus GVHD and disease recurrence.
Hematology. American Society of Hematology. Education Program - 1 Jan 2013
van Besien Koen
Abstract excerpt
Allogeneic transplantation constitutes curative treatment for acute myeloid leukemia and myelodysplastic syndrome. Its therapeutic effects are to a large extent mediated by GVL effects, but partially offset by treatment-related mortality and loss of quality of life caused by acute and chronic GVHD. Although severe acute and chronic GVHD are associated with a reduction in relapse risk, they are not associated with...
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