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Article

The Set2-RPB1 Interaction Domain of Human RECQ5 Is Important for Transcription-Associated Genome Stability

15 Mar 2011

Abstract excerpt

The conserved RECQ5 DNA helicase is a tumor suppressor in mammalian cells. Defects in RECQ5 lead to the accumulation of spontaneous DNA double-stranded breaks (DSBs) during replication, despite the fact that these cells are proficient in DSB repair by homologous recombination (HR). The reason for this is unknown. Here, we demonstrate that these DSBs are linked to RNA polymerase II (RNAPII)-dependent...

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PMID: 21402780
DOI: 10.1128/mcb.01137-10

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