Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human RECQL5 participates in the removal of endogenous DNA damage

13 Sept 2012

Abstract excerpt

Human RECQL5 is a member of the RecQ helicase family, which maintains genome stability via participation in many DNA metabolic processes, including DNA repair. Human cells lacking RECQL5 display chromosomal instability. We find that cells depleted of RECQL5 are sensitive to oxidative stress, accumulate endogenous DNA damage, and increase the cellular poly(ADP-ribosyl)ate response. In contrast to the RECQ helicase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22973052
DOI: 10.1091/mbc.e12-02-0110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human RECQL5 participates in the removal of endogenous DNA damagePMID 22973052Read ↗

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.Semantic proximity Read ↗

Human RECQL5β stimulates flap endonuclease 1Semantic proximity Read ↗

Human RECQL1 participates in telomere maintenanceSemantic proximity Read ↗

Human RecQ Helicases in DNA Double-Strand Break RepairSemantic proximity Read ↗

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and TranscriptionSemantic proximity Read ↗

PARP1 regulates RECQL4 recruitment for DNA double-strand break repairSemantic proximity Read ↗

RecQ Helicase Somatic Alterations in CancerSemantic proximity Read ↗

RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.Semantic proximity Read ↗

Unique and important consequences of RECQ1 deficiency in mammalian cellsSemantic proximity Read ↗

The involvement of human RECQL4 in DNA double‐strand break repairSemantic proximity Read ↗

Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.Semantic proximity Read ↗

RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.