Article
Contribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancer.
Oncogene - 11 Dec 2014
Haricharan S, Hein S M, Dong J, Toneff M J, Aina O H, Rao P H, Cardiff R D, Li Y
Abstract excerpt
Pregnancy-associated breast cancers (PABCs) are tumors diagnosed during pregnancy or up to 5 years following parturition, and are usually high-grade, connective tissue-rich, and estrogen receptor (ER)/progesterone receptor-negative. Little is known about the cellular origin of PABCs or the mechanisms by which PABCs are initiated. Using the RCAS retrovirus to deliver the ErbB2 oncogene into the mammary epithelium...
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