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Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions

27 May 2020

Abstract excerpt

Pregnancy causes a series of cellular and molecular changes in mammary epithelial cells (MECs) of female adults. In addition, pregnancy can also modify the predisposition of rodent and human MECs to initiate oncogenesis. Here, we investigate how pregnancy reprograms enhancer chromatin in the mammary epithelium of mice and influences the transcriptional output of the oncogenic transcription factor cMYC. We find...

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PMID: 32461571
DOI: 10.1038/s41467-020-16479-z

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