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Article

Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy.

eLife - 31 Dec 2013

Haricharan Svasti, Dong Jie, Hein Sarah, Reddy Jay P, Du Zhijun, Toneff Michael, Holloway Kimberly, Hilsenbeck Susan G, Huang Shixia, Atkinson Rachel, Woodward Wendy, Jindal Sonali, Borges Virginia F, Gutierrez Carolina, Zhang Hong, Schedin Pepper J, Osborne C Kent, Tweardy David J, Li Yi

Abstract excerpt

While a first pregnancy before age 22 lowers breast cancer risk, a pregnancy after age 35 significantly increases life-long breast cancer risk. Pregnancy causes several changes to the normal breast that raise barriers to transformation, but how pregnancy can also increase cancer risk remains unclear. We show in mice that pregnancy has different effects on the few early lesions that have already developed in the...

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Identifiers

PMID: 24381245
DOI: 10.7554/eLife.00996
PMCID: PMC3874103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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