Article
Hyperplasia and impaired involution in the mammary gland of transgenic mice expressing human FGF4.
Oncogene - 7 Dec 2000
Morini M, Astigiano S, Mora M, Ricotta C, Ferrari N, Mantero S, Levi G, Rossini M, Barbieri O
Abstract excerpt
Fgf4, a member of the fibroblast growth factor family, is frequently amplified in a variety of human cancers, however, its expression in neoplastic tissues is rarely detectable. This makes uncertain its involvement in tumour aetiology, although several in-vitro studies link Fgf4 overexpression to malignant transformation and metastatization of culture cells. We generated a transgenic mouse model in which the whey...
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