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Article

Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer.

Molecular cancer - 10 Jul 2024

Cifuentes Claudia, Oeste Clara L, Fernández-Pisonero Isabel, Hortal Alejandro M, García-Macías Carmen, Hochart Jeanne, Rubira Regina, Horndler Lydia, Horndler Carlos, Bustelo Xosé R, Alarcón Balbino

Abstract excerpt

BACKGROUND: Breast cancer (BC) is the most common cancer in women, with triple negative BC (TNBC) accounting for 20% of cases. While early detection and targeted therapies have improved overall life expectancy, TNBC remains resistant to current treatments. Although parity reduces the lifetime risk of developing BC, pregnancy increases the risk of developing TNBC for years after childbirth. Although numerous gene...

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Identifiers

PMID: 38987766
DOI: 10.1186/s12943-024-02054-3
PMCID: PMC11234613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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