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Article

Testing the iron hypothesis in a mouse model of atherosclerosis.

Cell reports - 12 Dec 2013

Kautz Léon, Gabayan Victoria, Wang Xuping, Wu Judy, Onwuzurike James, Jung Grace, Qiao Bo, Lusis Aldons J, Ganz Tomas, Nemeth Elizabeta

Abstract excerpt

Hepcidin, the iron-regulatory hormone and acute phase reactant, is proposed to contribute to the pathogenesis of atherosclerosis by promoting iron accumulation in plaque macrophages, leading to increased oxidative stress and inflammation in the plaque (the "iron hypothesis"). Hepcidin and iron may thus represent modifiable risk factors in atherosclerosis. We measured hepcidin expression in Apoe(-/-) mice with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24316081
DOI: 10.1016/j.celrep.2013.11.009
PMCID: PMC3880128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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