Article

Attenuating LRRK2 activity ameliorates progerin-induced aging phenotypes in HGPS models and during physiological aging

2026-08-07

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare premature aging disorder caused by progerin, a truncated lamin A variant generated by a silent de novo mutation activating a cryptic splice site in LMNA . The resulting morphological, epigenetic, genomic, and proteostasic defects closely recapitulate some hallmarks of cellular aging. Here, we identify the Parkinson’s disease-associated kinase LRRK2 as...

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Literature Corpus work: 604c0a4a-1dad-5a0d-be8a-dd9c94471747
DOI: 10.64898/2026.08.04.742751

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