Article

Development of an Accelerated Cellular Model for Alzheimer’s Disease

2023-05-10

Abstract excerpt

Alzheimer’s Disease (AD) is a leading cause of dementia characterized by amyloid plaques and neurofibrillary tangles, and its pathogenesis remains unclear. Current cellular models for AD often require several months to exhibit phenotypic features due to the lack of an aging environment in vitro. Lamin A is a key component of the nuclear lamina. And progerin, a truncated protein resulting from specific lamin A muta...

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Literature Corpus work: aeba0921-9bf8-5498-9677-1eff6959e47b
DOI: 10.1101/2023.05.09.539465

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