Article
Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.
Diabetes - 1 Mar 2014
Keildson Sarah, Fadista Joao, Ladenvall Claes, Hedman Åsa K, Elgzyri Targ, Small Kerrin S, Grundberg Elin, Nica Alexandra C, Glass Daniel, Richards J Brent, Barrett Amy, Nisbet James, Zheng Hou-Feng, Rönn Tina, Ström Kristoffer, Eriksson Karl-Fredrik, Prokopenko Inga, Spector Timothy D, Dermitzakis Emmanouil T, Deloukas Panos, McCarthy Mark I, Rung Johan, Groop Leif, Franks Paul W, Lindgren Cecilia M, Hansson Ola
Abstract excerpt
Using an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression quantitative trait loci [eQTLs]) as well as expression associated with measures of insulin...
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