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Article

Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure.

Development (Cambridge, England) - 1 Jan 2014

Hunter Ginger L, Crawford Janice M, Genkins Julian Z, Kiehart Daniel P

Abstract excerpt

We demonstrate that ion channels contribute to the regulation of dorsal closure in Drosophila, a model system for cell sheet morphogenesis. We find that Ca(2+) is sufficient to cause cell contraction in dorsal closure tissues, as UV-mediated release of caged Ca(2+) leads to cell contraction. Furthermore, endogenous Ca(2+) fluxes correlate with cell contraction in the amnioserosa during closure, whereas the...

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Identifiers

PMID: 24306105
DOI: 10.1242/dev.097097
PMCID: PMC3879814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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