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Article

Evidence for the mechanosensor function of filamin in tissue development.

Scientific reports - 6 Sept 2016

Huelsmann Sven, Rintanen Nina, Sethi Ritika, Brown Nicholas H, Ylänne Jari

Abstract excerpt

Cells integrate mechanical properties of their surroundings to form multicellular, three-dimensional tissues of appropriate size and spatial organisation. Actin cytoskeleton-linked proteins such as talin, vinculin and filamin function as mechanosensors in cells, but it has yet to be tested whether the mechanosensitivity is important for their function in intact tissues. Here we tested, how filamin mechanosensing...

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Identifiers

PMID: 27597179
DOI: 10.1038/srep32798
PMCID: PMC5011733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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