Article
Forces for morphogenesis investigated with laser microsurgery and quantitative modeling.
Science (New York, N.Y.) - 4 Apr 2003
Hutson M Shane, Tokutake Yoichiro, Chang Ming-Shien, Bloor James W, Venakides Stephanos, Kiehart Daniel P, Edwards Glenn S
Abstract excerpt
We investigated the forces that connect the genetic program of development to morphogenesis in Drosophila. We focused on dorsal closure, a powerful model system for development and wound healing. We found that the bulk of progress toward closure is driven by contractility in supracellular "purse strings" and in the amnioserosa, whereas adhesion-mediated zipping coordinates the forces produced by the purse strings...
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