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Article

Filamin protects myofibrils from contractile damage through changes in its mechanosensory region.

PLoS genetics - 1 Jun 2024

Fisher Lucas A B, Carriquí-Madroñal Belén, Mulder Tiara, Huelsmann Sven, Schöck Frieder, González-Morales Nicanor

Abstract excerpt

Filamins are mechanosensitive actin crosslinking proteins that organize the actin cytoskeleton in a variety of shapes and tissues. In muscles, filamin crosslinks actin filaments from opposing sarcomeres, the smallest contractile units of muscles. This happens at the Z-disc, the actin-organizing center of sarcomeres. In flies and vertebrates, filamin mutations lead to fragile muscles that appear ruptured,...

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Share to Actin Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mechanotransduction, Cellular

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Source

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Identifiers

PMID: 38905299
DOI: 10.1371/journal.pgen.1011101
PMCID: PMC11221683

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Filamin protects myofibrils from contractile damage through changes in its mechanosensory region.PMID 38905299Read ↗

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Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy.Semantic proximity Read ↗

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