Article
Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia.
Carcinogenesis - 1 May 2014
Kminkova Jana, Mraz Marek, Zaprazna Kristina, Navrkalova Veronika, Tichy Boris, Plevova Karla, Malcikova Jitka, Cerna Katerina, Rausch Tobias, Benes Vladimir, Brychtova Yvona, Doubek Michael, Mayer Jiri, Pospisilova Sarka
Abstract excerpt
MicroRNA (miRNA) expression is deregulated in many tumors including chronic lymphocytic leukemia (CLL). Although the particular mechanism(s) responsible for their aberrant expression is not well characterized, the presence of mutations and single-nucleotide polymorphisms (SNPs) in miRNA genes, possibly affecting their secondary structure and expression, has been described. In CLL; however, the impact and...
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