Article
MicroRNA in chronic lymphocytic leukemia: transitioning from laboratory-based investigation to clinical application.
Cancer genetics and cytogenetics - 1 Dec 2010
Nana-Sinkam S Patrick, Croce Carlo M
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is the most common form of leukemia among adults in the Western world, with an incidence of approximately 1 out of 100,000 patients per year. CLL is characterized by the clonal expansion of immature CD5(+) B cells. Although cytotoxic agents remain the mainstay of therapy, the disease of up to 20% of patients is not controlled with standard therapies. Therefore, there remains a...
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