A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.

doi:10.1056/NEJMoa050995

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Article

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.

The New England journal of medicine - 27 Oct 2005

Calin George Adrian, Ferracin Manuela, Cimmino Amelia, Di Leva Gianpiero, Shimizu Masayoshi, Wojcik Sylwia E, Iorio Marilena V, Visone Rosa, Sever Nurettin Ilfer, Fabbri Muller, Iuliano Rodolfo, Palumbo Tiziana, Pichiorri Flavia, Roldo Claudia, Garzon Ramiro, Sevignani Cinzia, Rassenti Laura, Alder Hansjuerg, Volinia Stefano, Liu Chang-gong, Kipps Thomas J, Negrini Massimo, Croce Carlo M

Abstract excerpt

BACKGROUND: MicroRNA expression profiles can be used to distinguish normal B cells from malignant B cells in patients with chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL. METHODS: We evaluated the microRNA expression profiles of 94 samples of CLL cells for which the level of expression of 70-kD zeta-associated protein (ZAP-70), the...

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PMID: 16251535
DOI: 10.1056/NEJMoa050995

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