Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression

4 Dec 2013

Abstract excerpt

The ubiquitin ligase CUL4A has been implicated in tumorigenesis, but its contributions to progression and metastasis have not been evaluated. Here, we show that CUL4A is elevated in breast cancer as well as in ovarian, gastric, and colorectal tumors in which its expression level correlates positively with distant metastasis. CUL4A overexpression in normal or malignant human mammary epithelial cells increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Research and Treatments
Share to Glycosylation and Glycoproteins Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24305877
DOI: 10.1158/0008-5472.can-13-2182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 ExpressionPMID 24305877Read ↗

CUL4A functions as an oncogene in ovarian cancer and is directly regulated by miR-494.Semantic proximity Read ↗

CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transitionSemantic proximity Read ↗

CUL4B enhances the malignant phenotype of esophageal squamous cell carcinoma by suppressing TGFBR3 expression.Semantic proximity Read ↗

Regulation of ZEB1 Function and Molecular Associations in Tumor Progression and MetastasisSemantic proximity Read ↗

Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapySemantic proximity Read ↗

HERC1 regulates breast cancer cells migration and invasionSemantic proximity Read ↗

CDKL2 promotes epithelial-mesenchymal transition and breast cancer progressionSemantic proximity Read ↗

CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseasesSemantic proximity Read ↗

CUL4B/miR‐33b/C‐MYC axis promotes prostate cancer progressionSemantic proximity Read ↗

The oncogenic E3 ligase TRIP12 suppresses epithelial–mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2Semantic proximity Read ↗

The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and metastasis-related processes through ZEB1/2Semantic proximity Read ↗

CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.