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Article

CUL4B enhances the malignant phenotype of esophageal squamous cell carcinoma by suppressing TGFBR3 expression.

Biochemical and biophysical research communications - 8 Oct 2023

Gong Qi, Wang Yuxing, Zhu Kexin, Bai Xueli, Feng Tong, Sun Gongping, Wang Molin, Pan Xiaohua, Qin Chengyong

Abstract excerpt

Cullin 4B (CUL4B), which acts as a scaffold protein in CUL4B-RING ubiquitin ligase complexes (CRL4B), is frequently overexpressed in cancer and represses tumor suppressors through epigenetic mechanisms. However, the expression and function of CUL4B in esophageal squamous cell carcinoma (ESCC) have not been well illustrated. In this study, we show that upregulation of CUL4B in ESCC cells enhances proliferation,...

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PMID: 37487438
DOI: 10.1016/j.bbrc.2023.07.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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