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Article

CUL4B/miR‐33b/C‐MYC axis promotes prostate cancer progression

4 Jan 2019

Abstract excerpt

BACKGROUND: Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, is overexpressed in many types of solid tumors and contributes to epigenetic silencing of tumor suppressors. However, its clinical significance and underlying molecular mechanisms in prostate cancer (PCa) remain unknown. METHODS: The clinical significance of CUL4B in PCa was characterized by in silico method....

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PMID: 30609075
DOI: 10.1002/pros.23754

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