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Article

Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction

3 Dec 2013

Abstract excerpt

Recent genetic studies have linked mental illness to alterations in disrupted in schizophrenia 1 (DISC1), a multifunctional scaffolding protein that regulates cyclic adenosine monophosphate (cAMP) signaling via interactions with phosphodiesterase 4 (PDE4). High levels of cAMP during stress exposure impair function of the prefrontal cortex (PFC), a region gravely afflicted in mental illness. As stress can...

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PMID: 24301646
DOI: 10.1038/tp.2013.104

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Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunctionPMID 24301646Read ↗

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