Article
RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling.
Blood - 16 Jan 2014
Kapralova Katarina, Lanikova Lucie, Lorenzo Felipe, Song Jihyun, Horvathova Monika, Divoky Vladimir, Prchal Josef T
Abstract excerpt
Overexpression of transcription factors runt-related transcription factor 1 (RUNX1) and nuclear factor, erythroid-derived 2 (NF-E2) was reported in granulocytes of patients with polycythemia vera and other myeloproliferative neoplasms (MPNs). Further, a transgenic mouse overexpressing the NF-E2 transgene was reported to be a model of MPN. We hypothesized that increased transcripts of RUNX1 and NF-E2 might...
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