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Article

Erythroid lineage-restricted expression of Jak2V617F is sufficient to induce a myeloproliferative disease in mice.

Haematologica - 1 Sept 2012

Akada Hajime, Akada Saeko, Hutchison Robert E, Mohi Golam

Abstract excerpt

The JAK2V617F mutation has been found in most cases of Ph-negative myeloproliferative neoplasms. Recent studies have shown that expression of Jak2V617F in the hematopoietic compartment causes marked expansion of erythroid progenitors and their transformation to cytokine-independence. To determine if erythroid progenitors are the target cells for induction and propagation of Jak2V617F-evoked myeloproliferative...

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Source

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Identifiers

PMID: 22371173
DOI: 10.3324/haematol.2011.059113
PMCID: PMC3436240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Erythroid lineage-restricted expression of Jak2V617F is sufficient to induce a myeloproliferative disease in mice.PMID 22371173Read ↗

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JAK2 V617F stimulates proliferation of erythropoietin-dependent erythroid progenitors and delays their differentiation by activating Stat1 and other nonerythroid signaling pathways.Semantic proximity Read ↗

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