Transcriptional profiling of polycythemia vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F.

doi:10.1158/1078-0432.CCR-10-1092

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Article

Transcriptional profiling of polycythemia vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2010

Berkofsky-Fessler Windy, Buzzai Monica, Kim Marianne K-H, Fruchtman Steven, Najfeld Vesna, Min Dong-Joon, Costa Fabricio F, Bischof Jared M, Soares Marcelo B, McConnell Melanie Jane, Zhang Weijia, Levine Ross, Gilliland D Gary, Calogero Raffaele, Licht Jonathan D

Abstract excerpt

PURPOSE: To understand the changes in gene expression in polycythemia vera (PV) progenitor cells and their relationship to JAK2V617F. EXPERIMENTAL DESIGN: Messenger RNA isolated from CD34(+) cells from nine PV patients and normal controls was profiled using Affymetrix arrays. Gene expression change mediated by JAK2V617F was determined by profiling CD34(+) cells transduced with the kinase and by analysis of...

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PMID: 20601445
DOI: 10.1158/1078-0432.CCR-10-1092
PMCID: PMC2947624

Genes

JAK2
KLF4
NFIB

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