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Article

Mutations in Pdd1 reveal distinct requirements for its chromodomain and chromoshadow domain in directing histone methylation and heterochromatin elimination.

Eukaryotic cell - 1 Feb 2014

Schwope Rachel M, Chalker Douglas L

Abstract excerpt

Pdd1, a specialized HP1-like protein, is required for genome-wide DNA rearrangements that restructure a previously silent germ line genome into an active somatic genome during macronuclear differentiation of Tetrahymena thermophila. We deleted or otherwise mutated conserved regions of the protein to investigate how its different domains promote the excision of thousands of internal eliminated sequences (IESs)....

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Share to DNA, Protozoan
Share to Heterochromatin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylation

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Share to Protein Processing, Post-Translational

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Identifiers

PMID: 24297443
DOI: 10.1128/EC.00219-13
PMCID: PMC3910979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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