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Article

Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe.

Eukaryotic cell - 1 Feb 2014

Mudge Dayna K, Yang Fan, Currie Brian M, Kim James M, Yeda Kelly, Bashyakarla Varoon K, Ivey F Douglas, Hoffman Charles S

Abstract excerpt

Schizosaccharomyces pombe detects extracellular glucose via a G protein-mediated cyclic AMP (cAMP)-signaling pathway activating protein kinase A (PKA) and regulating transcription of genes involved in metabolism and sexual development. In this pathway, Gpa2 Gα binds to and activates adenylyl cyclase in response to glucose detection by the Git3 G protein-coupled receptor. Using a two-hybrid screen to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24297439
DOI: 10.1128/EC.00277-13
PMCID: PMC3910974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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