Article
Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation.
Eukaryotic cell - 1 Aug 2002
Schadick Kevin, Fourcade H Matthew, Boumenot Peter, Seitz Jeffrey J, Morrell Jennifer L, Chang Louise, Gould Kathleen L, Partridge Janet F, Allshire Robin C, Kitagawa Katsumi, Hieter Phil, Hoffman Charles S
Abstract excerpt
The Schizosaccharomyces pombe fbp1 gene, encoding fructose-1,6-bisphosphatase, is transcriptionally repressed by glucose. Mutations that confer constitutive fbp1 transcription identify git (glucose-insensitive transcription) genes that encode components of a cyclic AMP (cAMP) signaling pathway required for adenylate cyclase activation. Four of these genes encode the three subunits of a heterotrimeric G protein...
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