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Article

Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1.

PLoS genetics - 1 Jul 2021

Li Shuang, Li Yuanyuan, Rushing Blake R, Harris Sarah E, McRitchie Susan L, Jones Janice C, Dominguez Daniel, Sumner Susan J, Dohlman Henrik G

Abstract excerpt

Heterotrimeric G proteins were originally discovered through efforts to understand the effects of hormones, such as glucagon and epinephrine, on glucose metabolism. On the other hand, many cellular metabolites, including glucose, serve as ligands for G protein-coupled receptors. Here we investigate the consequences of glucose-mediated receptor signaling, and in particular the role of a Gα subunit Gpa2 and a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34214075
DOI: 10.1371/journal.pgen.1009640
PMCID: PMC8282090

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