Article
Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.
Eukaryotic cell - 1 Jun 2004
Stiefel Jeffrey, Wang Lili, Kelly David A, Janoo Rozmin T K, Seitz Jeffrey, Whitehall Simon K, Hoffman Charles S
Abstract excerpt
Schizosaccharomyces pombe utilizes two opposing signaling pathways to sense and respond to its nutritional environment. Glucose detection triggers a cyclic AMP signal to activate protein kinase A (PKA), while glucose or nitrogen starvation activates the Spc1/Sty1 stress-activated protein kinase (SAPK). One process controlled by these pathways is fbp1+ transcription, which is glucose repressed. In this study, we...
Topics
- Adenylyl Cyclases
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Gene Expression Regulation, Fungal
- Glucose
- MAP Kinase Kinase 4
- Mutation
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Sequence Deletion
- Signal Transduction
