Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.

Eukaryotic cell - 1 Apr 2010

Ivey F Douglas, Taglia Francis X, Yang Fan, Lander Matthew M, Kelly David A, Hoffman Charles S

Abstract excerpt

The Schizosaccharomyces pombe glucose/cyclic AMP (cAMP) signaling pathway includes the Gpa2-Git5-Git11 heterotrimeric G protein, whose Gpa2 Galpha subunit directly binds to and activates adenylate cyclase in response to signaling from the Git3 G protein-coupled receptor. To study intrinsic and extrinsic regulation of Gpa2, we developed a plasmid-based screen to identify mutationally activated gpa2 alleles that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to GTP-Binding Protein alpha Subunits

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guanosine Diphosphate

Share to Guanosine Triphosphate

Share to Heterotrimeric GTP-Binding Proteins

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 20139237
DOI: 10.1128/EC.00010-10
PMCID: PMC2863420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.PMID 20139237Read ↗

Second site suppressor mutations of a GTPase-deficient G-protein alpha-subunit. Selective inhibition of Gbeta gamma-mediated signaling.Semantic proximity Read ↗

Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.Semantic proximity Read ↗

Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).Semantic proximity Read ↗

The fission yeast git5 gene encodes a Gbeta subunit required for glucose-triggered adenylate cyclase activation.Semantic proximity Read ↗

Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.Semantic proximity Read ↗

The git5 Gbeta and git11 Ggamma form an atypical Gbetagamma dimer acting in the fission yeast glucose/cAMP pathway.Semantic proximity Read ↗

Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe.Semantic proximity Read ↗

Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.Semantic proximity Read ↗

The GTP hydrolysis defect of the Saccharomyces cerevisiae mutant G-protein Gpa1(G50V).Semantic proximity Read ↗

Effects of mutations in the N terminal region of the yeast G protein alpha-subunit Gpa1p on signaling by pheromone receptors.Semantic proximity Read ↗

Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition.Semantic proximity Read ↗

Gib2, A Novel Gβ-like/RACK1 Homolog, Functions as a Gβ Subunit in cAMP Signaling and Is Essential in Cryptococcus neoformansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.