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Article

Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition.

The Journal of biological chemistry - 10 Jan 2014

Villarejo Ana, Cortés-Cabrera Alvaro, Molina-Ortíz Patricia, Portillo Francisco, Cano Amparo

Abstract excerpt

Snail1 (Snail) and Snail2 (Slug) are transcription factors that share a similar DNA binding structure of four and five C2H2 zinc finger motifs (ZF), respectively. Both factors bind specifically to a subset of E-box motifs (E2-box: CAGGTG/CACCTG) in target promoters like the E-cadherin promoter and are key mediators of epithelial-to-mesenchymal transition (EMT). However, there are differences in the biological...

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Identifiers

PMID: 24297167
DOI: 10.1074/jbc.M113.528026
PMCID: PMC3887216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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