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Article

Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer

1 Dec 2018

Abstract excerpt

BACKGROUND: The transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involved in this process in human colorectal cancer (CRC) remain largely unknown. METHOD: We checked the expression of Snail2 in several clinical CRC specimens. Then, we established Snail2-overexpressing and knockdown cell lines to determine the function of Snail2 during EMT...

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PMID: 30541610
DOI: 10.1186/s13148-018-0592-y

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