Article
Physiologic characterization of type 2 diabetes-related loci.
Current diabetes reports - 1 Dec 2010
Grarup Niels, Sparsø Thomas, Hansen Torben
Abstract excerpt
For the past two decades, genetics has been widely explored as a tool for unraveling the pathogenesis of diabetes. Many risk alleles for type 2 diabetes and hyperglycemia have been detected in recent years through massive genome-wide association studies and evidence exists that most of these variants influence pancreatic β-cell function. However, risk alleles in five loci seem to have a primary impact on insulin...
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