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Article

Mutated CaV2.1 channels dysregulate CASK/P2X3 signaling in mouse trigeminal sensory neurons of R192Q Cacna1a knock-in mice.

Molecular pain - 2 Dec 2013

Gnanasekaran Aswini, Bele Tanja, Hullugundi Swathi, Simonetti Manuela, Ferrari Michael D, van den Maagdenberg Arn M J M, Nistri Andrea, Fabbretti Elsa

Abstract excerpt

BACKGROUND: ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of pain as they adapt their expression and function in response to acute and chronic nociceptive signals. The present study investigated the role of calcium/calmodulin-dependent serine protein kinase (CASK) in controlling P2X3 receptor expression and function in trigeminal ganglia from Cacna1a R192Q-mutated knock-in (KI)...

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Source

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Identifiers

PMID: 24294842
DOI: 10.1186/1744-8069-9-62
PMCID: PMC4220808

Genes

CASK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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