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Article

A host deficiency of discoidin domain receptor 2 (DDR2) inhibits both tumour angiogenesis and metastasis.

The Journal of pathology - 1 Mar 2014

Zhang Shuya, Bu Xin, Zhao Hu, Yu Jiangtian, Wang Yingmei, Li Di, Zhu Chuchao, Zhu Tong, Ren Tingting, Liu Xinping, Yao Libo, Su Jin

Abstract excerpt

Discoidin domain receptor 2 (DDR2) is a unique receptor tyrosine kinase (RTK) that signals in response to collagen binding and is implicated in tumour malignant phenotypes such as invasion and metastasis. Although it has been reported that DDR2 expression is up-regulated in activated endothelial cells (ECs), functional studies are lacking. Herein, we found that enforced expression of DDR2 promoted proliferation,...

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Share to Endothelial Cells
Share to Human Umbilical Vein Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma, Experimental

Share to Neovascularization, Pathologic

Share to Neovascularization, Physiologic

Share to Receptor Protein-Tyrosine Kinases

Share to Receptors, Mitogen

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Source

Identifiers

PMID: 24293323
DOI: 10.1002/path.4311

Genes

DDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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