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Article

Discoidin Domain Receptor 1 Contributes to Tumorigenesis through Modulation of TGFBI Expression

4 Nov 2014

Abstract excerpt

Discoidin domain receptor 1 (DDR1) is a member of the receptor tyrosine kinase family. The receptor is activated upon binding to its ligand, collagen, and plays a crucial role in many fundamental processes such as cell differentiation, adhesion, migration and invasion. Although DDR1 is expressed in many normal tissues, upregulated expression of DDR1 in a variety of human cancers such as lung, colon and brain...

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PMID: 25369402
DOI: 10.1371/journal.pone.0111515

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