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Article

FOXD1 promotes dedifferentiation and targeted therapy resistance in melanoma by regulating the expression of connective tissue growth factor.

International journal of cancer - 1 Aug 2021

Sun Qian, Novak Daniel, Hüser Laura, Poelchen Juliane, Wu Huizi, Granados Karol, Federico Aniello, Liu Ke, Steinfass Tamara, Vierthaler Marlene, Umansky Viktor, Utikal Jochen

Abstract excerpt

Metastatic melanoma is an aggressive skin cancer and associated with a poor prognosis. In clinical terms, targeted therapy is one of the most important treatments for patients with BRAFV600E -mutated advanced melanoma. However, the development of resistance to this treatment compromises its therapeutic success. We previously demonstrated that forkhead box D1 (FOXD1) regulates melanoma migration and invasion....

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PMID: 33837564
DOI: 10.1002/ijc.33591

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