Article
Robust joint analysis with data fusion in two-stage quantitative trait genome-wide association studies.
Computational and mathematical methods in medicine - 1 Jan 2013
Pan Dong-Dong, Xiong Wen-Jun, Zhou Ji-Yuan, Pan Ying, Zhou Guo-Li, Fung Wing-Kam
Abstract excerpt
Genome-wide association studies (GWASs) in identifying the disease-associated genetic variants have been proved to be a great pioneering work. Two-stage design and analysis are often adopted in GWASs. Considering the genetic model uncertainty, many robust procedures have been proposed and applied in GWASs. However, the existing approaches mostly focused on binary traits, and few work has been done on continuous...
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