Article
BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from Denmark.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2008
Soegaard Marie, Kjaer Susanne Kruger, Cox Mark, Wozniak Eva, Høgdall Estrid, Høgdall Claus, Blaakaer Jan, Jacobs Ian J, Gayther Simon A, Ramus Susan J
Abstract excerpt
PURPOSE: To evaluate the prevalence of BRCA1 and BRCA2 mutations and associations with clinical correlates of disease in a population-based series of ovarian cancer cases from Denmark. METHODS: DNA sequencing and multiplex ligation-dependent probe amplification analysis were used to analyze the BRCA1 and BRCA2 genes for coding sequence mutations and large genomic rearrangements in 445 confirmed cases of ovarian...
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