Article
Large regional differences in the frequency of distinct BRCA1/BRCA2 mutations in 517 Dutch breast and/or ovarian cancer families.
European journal of cancer (Oxford, England : 1990) - 1 Nov 2001
Verhoog L C, van den Ouweland A M, Berns E, van Veghel-Plandsoen M M, van Staveren I L, Wagner A, Bartels C C, Tilanus-Linthorst M M, Devilee P, Seynaeve C, Halley D J, Niermeijer M F, Klijn J G, Meijers-Heijboer H
Abstract excerpt
In 517 Dutch families at a family cancer clinic, we screened for BRCA1/2 alterations using the Protein Truncation Test (PTT) covering approximately 60% of the coding sequences of both genes and direct testing for a number of previously identified Dutch recurrent mutations. In 119 (23%) of the 517 families, we detected a mutation in BRCA1 (n=98; 19%) or BRCA2 (n=21; 4%). BRCA1/2 mutations were found in 72 (52%) of...
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