Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE.

doi:10.1093/jnci/djt095

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Article

Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE.

Journal of the National Cancer Institute - 5 Jun 2013

Mavaddat Nasim, Peock Susan, Frost Debra, Ellis Steve, Platte Radka, Fineberg Elena, Evans D Gareth, Izatt Louise, Eeles Rosalind A, Adlard Julian, Davidson Rosemarie, Eccles Diana, Cole Trevor, Cook Jackie, Brewer Carole, Tischkowitz Marc, Douglas Fiona, Hodgson Shirley, Walker Lisa, Porteous Mary E, Morrison Patrick J, Side Lucy E, Kennedy M John, Houghton Catherine, Donaldson Alan, Rogers Mark T, Dorkins Huw, Miedzybrodzka Zosia, Gregory Helen, Eason Jacqueline, Barwell Julian, McCann Emma, Murray Alex, Antoniou Antonis C, Easton Douglas F

Abstract excerpt

BACKGROUND: Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for breast cancer, ovarian cancer, and contralateral breast cancer in a prospective series of mutation carriers and to assess how these risks are modified by common breast cancer susceptibility alleles. METHODS: Prospective cancer risks...

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PMID: 23628597
DOI: 10.1093/jnci/djt095

Genes

BRCA2
BRCA1

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