Article
Pediatric thalamic glioma with H3F3A K27M mutation, which was detected before and after malignant transformation: a case report.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Dec 2016
Ishibashi Kenichi, Inoue Takeshi, Fukushima Hiroko, Watanabe Yusuke, Iwai Yoshiyasu, Sakamoto Hiroaki, Yamasaki Kai, Hara Jyunichi, Shofuda Tomoko, Kanematsu Daiksuke, Yoshioka Ema, Kanemura Yonehiro
Abstract excerpt
PURPOSE: Histone H3.3 (H3F3A) mutation in the codon for lysine 27 (K27M) has been found as driver mutations in pediatric glioblastoma and has been suggested to play critical roles in the pathogenesis of thalamic gliomas and diffuse intrinsic pontine gliomas. We report a case of thalamic glioma with H3F3A K27M mutation, which was detected in both the primary tumor diagnosed as diffuse astrocytoma obtained during...
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