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Identification of senescence-inducing microRNAs in normal human keratinocytes

1 Jul 2011

Abstract excerpt

MicroRNAs (miRNAs) are epigenetic regulators of eukaryotic gene expression and play key roles in many cellular processes. However, the role of miRNAs for replicative senescence of normal human keratinocytes (NHKs) remains unknown. Thus, we examined the expression profiles of 847 miRNAs in exponentially replicating and senescent NHKs and identified 126 senescence-associated miRNAs (SA-miRs). Among SA-miRs, 117...

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PMID: 21725593
DOI: 10.3892/ijo.2011.1111

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