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Article

Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human.

PloS one - 1 Jan 2017

Krauskopf Julian, de Kok Theo M, Schomaker Shelli J, Gosink Mark, Burt Deborah A, Chandler Patricia, Warner Roscoe L, Johnson Kent J, Caiment Florian, Kleinjans Jos C, Aubrecht Jiri

Abstract excerpt

MicroRNAs (miRNAs) released into the peripheral circulation upon cellular injury have shown a promise as a new class of tissue-specific biomarkers. We were first to demonstrate that next-generation sequencing analysis of serum from human subjects with acetaminophen-induced liver injury revealed a specific signature of circulating miRNAs. We consequently hypothesized that different types of hepatic liver...

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PMID: 28545106
DOI: 10.1371/journal.pone.0177928
PMCID: PMC5435338

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